A few people were asking for a quick reference regarding age related proBNP cutoffs.
Embedded below are links to both the PRIDE and ICON-RELOADED trials which investigated proBNP cutoffs in the emergency department.
The optimal age-independent cutoff for ruling out acute heart failure is <300 pg/ml
The optimal age-adjusted cutoffs for ruling in acute heart failure are:
<50 years old – 450 pg/ml
50-75 years old – 900 pg/ml
>75 years old – 1800 pg/mldoi_10.1016_j.amjcard.2004.12.032