proBNP cutoffs

A few people were asking for a quick reference regarding age related proBNP cutoffs.

Embedded below are links to both the PRIDE and ICON-RELOADED trials which investigated proBNP cutoffs in the emergency department.

In summary:

The optimal age-independent cutoff for ruling out acute heart failure is <300 pg/ml

The optimal age-adjusted cutoffs for ruling in acute heart failure are:

<50 years old – 450 pg/ml

50-75 years old – 900 pg/ml

>75 years old – 1800 pg/ml